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Our research is driven by the desire to understand the interaction of microorganisms and cells with polymer materials to inspire the development of environmentally friendly antifouling and biomedical coatings. Surface modification and polymer synthesis in conjunction with advanced surface characterization is used to correlate surface properties with biological response for a knowledge driven development of new coating technologies. To gain a deeper insight into the structure and dynamics of surface colonization by microorganisms, we develop and apply microfluidic assays, 3D tracking techniques, and X-ray nanoanalysis.